AZ ROC: CR-42 320942
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2012 AACR Poster: Synergistic inhibition of tumor growth and overcoming resistance in Lung Cancer by combining novel dual-targeting DNA-alkylating/HDAC inhibitor with Tumor Suppressor NPRL2- and p53-nanoparticles

DNA alkylating agents such as platinum and nitrogen mustard are effective cancer chemotherapeutics. They kill proliferating tumor cells by inducing high levels of DNA damage leading to cell-cycle arrest and cell death. However, their highly toxic side effects and the common drug resistance exhibited in tumors limit their anticancer efficacy and clinical benefits. Here we describe a novel anticancer therapeutic strategy using a new class of rationally designed dual DNA alkylating/HDAC inhibitors combined with nanovesicle-mediated gene therapy targeting the DNA damage/repair pathway in human NSCLC and SCLC cells.